Expiration date: 08/2025
release Form
Capsules of prolonged action
Composition
1 caps. It contains 30 mg of urapidil
Packaging
30 pcs.
pharmachologic effect
Ebrantil relates to drugs blocking the postsynaptic alpha-1 adrenergic receptors, thereby reducing peripheral resistance. In addition, Ebrantil controls the central mechanism for maintaining vascular tone and has a weak beta-adrenoceptor blocking action. Heart rate (HR), cardiac output when administered not change. Low cardiac output can be increased by reducing vascular resistance. Orthostatic effects usually does not cause Ebrantil. Ebrantil blocks vasoconstriction caused by alpha-2 adrenoceptors, and does not cause reflex tachycardia due to vasodilation. Ebrantil balanced reduced systolic and diastolic blood pressure (BP) by reducing peripheral resistance and does not cause reflex tachycardia. Urapidil reduces pre- and afterload on the heart, increases the efficiency of cardiac contraction, thereby, in the absence of arrhythmia, drug increases cardiac output decreased.
testimony
Hypertensive crisis, refractory and severe hypertension. Controlled hypotension during and / or after surgery.
Contraindications
Hypersensitivity to the drug, aortic stenosis, open arterial canal, up to age 18 years, pregnancy, lactation (effectiveness and safety have been established).
Precautions: older age, the liver and / or kidneys, hypovolemia.
Dosing and Administration
The drug is administered at a dose of 30 mg (1 capsule). 2 times / day.
If you want a more rapid decrease in blood pressure, the dose may be increased to Ebrantila 60 mg (2 caps.) 2 times / day.
The dose should be adjusted individually. The average daily dosage should be from 60 to 180 mg, divided into 2 doses.
The capsules should be taken 2 times / day., Morning and evening, with a meal, washed down with a little water.
Side effects
Most PE due to a sharp decrease in blood pressure.
Frequency: very often - more than 1/10, often - more than 1/100 and less than 1/10, rarely - more than 1/1000 and less than 1/100, rarely - more than 1/10000 and less than 1/1000, very rare - less 1/10000, including individual messages.
From the CCC: rarely - palpitations, tachycardia, bradycardia, a sense of compression in the chest, shortness of breath, arrhythmia.
From the digestive system: often - nausea, rarely - vomiting.
CNS: often - dizziness, headache, fatigue, very rare - anxiety.
For the skin: rarely - increased sweating.
Allergic reactions: rarely - itching, redness of the skin rash.
With the genitourinary system: often - proteinuria, rarely - nephropathy, nephrotic syndrome, rarely - priapism.
Laboratory findings: very rarely - thrombocytopenia.
Drug interactions
The antihypertensive effect may be enhanced when urapidil joint reception with alpha-blockers and other antihypertensive agents, as well as hypovolemia (nausea, vomiting), and upon receipt of ethanol.
At the same time taking cimetidine urapidil maximum concentration in the blood plasma can be increased by 15%.
Overdose
Symptoms: dizziness, orthostatic collapse, fatigue, lethargy.
Treatment: the sudden fall in blood pressure is necessary to raise the patient's leg and begin infusion therapy to increase blood volume. With the ineffectiveness of these measures can begin infusion of vasoconstrictor, blood pressure under control. In very rare cases it is necessary intravenous catecholamines (0.5 - 1.0 mg of epinephrine (adrenaline), diluted in 10 ml saline).
Storage conditions
Store at temperatures not above 30 ° C. Keep out of the reach of children.
