Expiration date: 01/2025

Composition and form of issue:

Tablets. 1 tablet contains:

diosmin 600 mg

excipients: povidone MCC starch corn magnesium stearate purified water (not contained in the finished product) 

blistere in 15 PCs the paper cartons 2 blister.

Description of dosage form:

Oblong tablets from grayish-yellow to light yellow with a fault line on both sides.

Pharmacokinetics:

After oral administration, the drug is rapidly absorbed from the gastrointestinal tract and is determined in the blood plasma through 2 no.Smahv blood plasma is achieved through 5 h after administration. Evenly distributed and accumulated in all layers of the wall of hollow veins and subcutaneous veins of the lower extremities, to a lesser extent — in the kidneys, liver, lungs and other organs. Selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by the 9th hour after administration and persists for 96 hours.diosmin is Excreted in the urine-79%, with feces — 11%, with bile — 2, 4%.

Description of pharmacological action:

Diosmin has venotonic effect (reduces the distensibility of veins, increases venous tone (dose dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increasing their functional density, reduces lymphatic pressure), improves (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduce leukocyte adhesion to the venous wall and their migration into paravenoznoe tissue, improves the diffusion of oxygen and perfusion in skin tissue, it has an anti-inflammatory effect. It enhances the vasoconstrictive effect of adrenaline, norepinephrine, serotonin, blocks the production of free radicals, the synthesis of PG and thromboxane.

Indications:

• varicose veins of the lower extremities
  
• chronic lymphovenous insufficiency of the lower extremities
  
• exacerbation of hemorrhoids
  
• microcirculation disorders.
  

Contraindications:

• hypersensitivity to the drug components
  
• children (under 18 years).
  

Use during pregnancy and breast-feeding:

Until now, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. In experimental studies, there was no teratogenic effect on the fetus.

During breastfeeding, it is not recommended to take the drug, because there are no data on the penetration of the drug into breast milk.

Side effect:

On the part of the digestive tract:rarely — diarrhoea disorders.

CNS:headache.

Drug interaction:

Clinically significant effects of interaction with other drugs are not described.

Dosage and administration:

Inside.

With varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in the legs)— 1 table. a day in the morning, before Breakfast. The duration of treatment — for 2 months, with severe forms of chronic lymphovenous insufficiency (swelling, pain, convulsions, etc.) — for 3-4 months, in the presence of trophic changes and ulcers — up to 6 months or more. The course is repeated after 2-3 months.

With exacerbation of hemorrhoids-2-3 table. per day during meals for 7 days, then if necessary, you can continue to 1 table. 1 time per day for 1-2 months.

In the treatment of chronic lymphovenous insufficiency during the II and III trimester of pregnancy-1 table. 1 time a day and cancel 2-3 weeks before delivery.

If you miss 1 or more doses, then you should continue to use the drug in the usual dosage.

Overdose:

The symptoms of overdose are not described.

Special instruction:

Treatment of exacerbation of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct additional examination and adjust the therapy.

There is evidence of the possible effectiveness of the drug in the treatment of fetoplacental insufficiency, for the prevention of bleeding, arising from the use of intrauterine spirals and during phlebectomy.