Expiration date: 01/2025
Vetbicin-5 is a long-acting medicinal antibacterial agent in the form of a powder for the preparation of an injectable solution. It is a white or white powder with a yellowish tinge of color, with water it forms a stable suspension.
COMPOSITION AND FORM OF RELEASE
1 bottle of Vetbicin-5 contains as active substances a mixture of two antibiotics: benzatin benzylpenicillin - 1 200 000 UNITS and benzylpenicillin novocaine salt-300 000 units.
PHARMACOLOGICAL PROPERTIES
Vetbicin-5 is a complex antibacterial agent containing two biosynthetic penicillins. The drug is active against Gram-positive microorganisms, including Staphylococcus spp., Streptococcus pneumoniae, Corynebacterium diphtheriae, anaerobic spore-forming rods, Bacillus anthracis and Gram-negative microorganisms, including Neisseria meningitidis, Actinomyces israelii, as well as against Treponema spp. The mechanism of the bactericidal action of penicillins is based on the violation of the synthesis of peptidoglycan (mucopeptide), which is part of the cell wall of microorganisms, by inhibiting the enzymes transpeptidase and carboxypeptidase, which leads to a violation of the osmotic balance and destruction of the bacterial cell. After intramuscular administration, Vetbicin-5 is absorbed into the blood and remains in therapeutic concentration for 7 to 10 days. It is excreted mainly in the urine and partly in the feces. Vetbicin-5, according to the degree of exposure to the body of warm-blooded animals, belongs to the 3rd class of danger (moderately dangerous substances).
INDICATIONS
Vetbicin-5 is prescribed to large and small cattle, horses, pigs, fur-bearing animals, rabbits, turkeys, geese and ducks for the treatment of infectious diseases caused by microorganisms sensitive to benzylpenicillin.
DOSAGE AND METHOD OF ADMINISTRATION
Before use, 5-6 ml of water for injection (or a sterile isotonic solution of sodium chloride, or 1 – 2% sterile solution of novocaine) is added to the bottle with Vetbicin – 5, puncturing the cap and stopper, and the bottle is thoroughly shaken until a homogeneous suspension is formed, which is immediately administered to the animal deeply intramuscularly. If the needle gets into the vessel and a drop of blood appears, the needle must be removed and the injection repeated in another place. The resulting suspension is administered to animals once in the following single doses:
Cattle 10,000 -15,000 units per 1 kg of animal weight
Horses 10 000-20 000 units per 1 kg of animal weight
Small cattle 15 000-20 000 units per 1 kg of animal weight
Pigs 15 000-20 000 units per 1 kg of animal weight
Fur-bearing animals 50 000-60 000 units per 1 kg of animal
Rabbits 40 000-50 000 units per 1 kg of animal
Turkeys, geese, ducks 100 000 units per 1 kg of poultry weight
If necessary, Vetbicin-5 is reused after 7 to 10 days.
SIDE EFFECTS
Hypersensitive animals may have allergic reactions. With increased individual sensitivity of the animal to penicillin-type antibiotics and the appearance of allergic reactions, the use of the drug is discontinued and desensitizing therapy is performed.
CONTRAINDICATIONS
Increased individual sensitivity to the components of the drug.
SPECIAL INSTRUCTIONS
Slaughter of animals for meat is allowed 14 days after the last application of Vetbicin-5. The meat of animals forcibly killed before the expiration of the specified period can be used as food for fur-bearing animals. Milk from dairy animals obtained during the treatment period and within 7 days after the last administration of Vetbicin-5 is forbidden to be used for food purposes. Such milk can be used after heat treatment for feeding animals.
SHELF LIFE AND STORAGE
Store with List B caution. In a dry place, protected from direct sunlight and out of the reach of children and animals, at a temperature of 5 to 25 °C. Shelf life — 3 years.
PACKAGING
They are packaged in hermetically sealed glass bottles with a capacity of 10 ml, capped with rubber stoppers and rolled with aluminum caps.
