Expiration date: 03/2025
Structure and Composition:
Dragee. 1 dragee contains:
benfotiamine 100 mg
pyridoxine hydrochloride 100 mg
Excipients: povidone MCC omega-3 triglycerides colloidal silicon dioxide carmellose sodium talc, shellac, sucrose, calcium carbonate, acacia gum, corn starch titanium dioxide, macrogol 6000 glycerol 85%, polysorbate-80 mountain glycol wax
in blister 15 pcs. in box 2 or 4 blisters.
Description pharmaceutical form:
Dragee - round, biconcave, white.
Description of the pharmacological actions:
Neurotropic B vitamins have a beneficial effect in inflammatory and degenerative diseases of the nerves and musculoskeletal system, in high doses have an analgesic effect, promote blood flow and normalize the nervous system and the process of hematopoiesis. Thiamine plays a key role in the metabolism of carbohydrates, and in the Krebs cycle with subsequent participation in the synthesis of TPP (thiamine pyrophosphate), and ATP (adenosine triphosphate) .Piridoksin involved in protein metabolism. The physiological function of both vitamins is a potentiation of each other, which manifests itself in a positive impact on the nervous system. Cyanocobalamin is involved in the synthesis of the myelin sheath, reduces pain associated with a lesion of the peripheral nervous system stimulates nucleic exchange via folate activation. Lidocaine - local anesthetic, causing all kinds of local anesthesia: terminal, infiltration, and conductors.
Testimony:
Nervous system diseases of various origins:
- pain (radiculopathy, sciatica, muscular-tonic syndromes)
- neuropathy (diabetic, alcohol, etc.).
- neuritis and polyneuritis, including optic neuritis
- peripheral paresis, including facial nerve
- neuralgia, including trigeminal nerve and intercostal nerves.
Contraindications:
- hypersensitivity (including to the individual components)
- severe and acute form of decompensated heart failure
- infancy, due to lack of data.
Application of pregnancy and breastfeeding:
Not recommended.
Side effect:
Sweating, tachycardia, acne, and other systemic reactions (rr d / in at a very rapid introduction.), Allergic reactions: skin rash, urticaria, pruritus, bronchospasm, angioedema, anaphylactic shock.
Drug Interactions:
Thiamine completely dissolves in solutions containing sulphites. Levodopa reduces the effect of therapeutic doses of vitamin B6.
Possible interaction with cycloserine, D-penicillamine, adrenaline, noradrenaline, sulfonamides.
Incompatible with oxidizing substances, as well as phenobarbital, riboflavin, benzylpenicillin, glucose, metabisulfite, heavy metal salts. Copper accelerates the decomposition of thiamine, moreover, thiamine loses its effect when more than 3 pH.
Dosage and administration:
In cases of severe pain syndrome treatment it is advisable to start with the / m (deep) Milgamma 2 ml of the drug daily for 5-10 days with the transition in the future or to ingestion of pills Milgamma kompozitum or the more rare injections (2-3 times week).
