Expiration date: 05/2025

The composition and form of issue:

The oral solution 20% 100ml

active substances:

acetylglutamine acid (N-acetyl-L-glutamic acid) 13, 6 g

deanol (2-(dimethylamino)-ethanol) 6, 4 g

excipients: 

33 mg of methyl parahydroxybenzoate

parahydroxybenzoate 16, 7 mg

xylitol (xylitol) 1 g

purified water to 100 ml

in dark glass bottles with screw neck, plastic-sealed screw caps, 100 ml in a cardboard pack 1 bottle.

Description pharmaceutical form:

Liquid with a pinkish or yellowish tint with a specific smell.

Pharmacokinetics:

Through 0, 5-1 h after an oral dose is found in maximum concentration in the brain in smaller amounts in liver, heart, lungs, blood plasma, kidney. The elimination half-life (T1/2) — 24 hours Excreted by the kidneys.

Description pharmacological action:

Nooclerin — is a nootropic drug, on chemical structure similar to natural metabolites of the brain (GABA, glutamic acid). Exerts neuroprotective activity, helps to improve memory and learning process has a positive effect in asthenic and dinamicheskih disorders, improving motor and mental activity of patients.

When using the drug improves the ability to concentrate. Nooclerin has a positive effect with neurotic condition in elderly and senile age, which developed on the background of organic insufficiency of the brain, alcohol-withdrawal syndrome.

Dosage:

INSTRUCTIONS for medical use of the drug NOOCLERIN (NOOCLERINUM)

APPROVED

Pharmacological Committee of 14 June 2001, the Protocol 4B

Description

Slightly colored liquid of sour taste and odor.

Composition

100 ml of solution contain: acid N-acetyl-L-glutamic — 13, 6 g,

2-(dimethylamino)-ethanol — 6, 4 g.

Excipients: peroxybenzoyl acid, methyl ester, acid para - hydroxybenzoic, propyl ether, xylitol, purified water.

Pharmacological properties

Pharmacodynamics

On chemical structure similar to natural metabolites of the brain (GABA, glutamic acid). The drug has a cerebroprotective properties with a distinct nootropic, stimulating and psychogerontology action. Helps to improve memory and learning process has a positive effect in asthenic and dinamicheskih disorders, improving motor and mental activity of patients, improves the ability to concentrate. Nooclerin has a positive effect with neurotic condition in elderly and senile age, which developed on the background of organic insufficiency of the brain in alcohol-withdrawal syndrome.

Pharmacokinetics

After ingestion through 0, 5-1 h found Cmax in the brain and liver, and in smaller amounts in lung, heart, blood plasma, the kidneys. Excreted by the kidneys.

Testimony

• In the period of convalescence after suffering a traumatic brain injury and vascular brain disease (especially in elderly and senile age).
  
• Asthenic and astenodepressivnyh disorders, psychoorganic syndrome.
  
• The relief (in complex therapy) alcohol withdrawal syndrome.
  
• Use as a means of improving the intellectual-mnestic functions.
  

Method of application and doses

Inside usually 1 teaspoon (5 ml contains 1 g of active ingredient) 2 to 3 times a day. Last admission no later than 4 hours before bedtime. The maximum single dose 2 g (2 tsp). The maximum daily dose of 10 g (10 h. spoons). Treatment 1, 5-2, 5 months 2-3 times a year.

Contraindications

Hypersensitivity to the drug, infectious diseases, Central nervous system, fevers, blood disease, psychotic state, expressed human liver and kidneys, pregnancy (I trimester), lactation.

Side effects

Allergic reactions are possible.

In some cases of depression in the elderly.

Interaction

May increase the action of drugs that stimulate the Central nervous system.

Overdose

In case of overdose is increased symptoms side effects of the drug. First aid is the elimination of the drug, administration of activated charcoal. If necessary, — symptomatic therapy.

Special instructions

Use caution when working with machinery.

Release form

In bottles of 50, 100, 200 ml.

Storage conditions

List B. In the dark place at temperatures not above 25 °C. Keep out of the reach of children.

Shelf life

2 years. At the opening of the bottle should be stored in the refrigerator at a temperature of 4-8 °C. do Not use after expiry date printed on the label.

Manufacturer

Institute of molecular genetics RAS, on the order of "PIK-PHARMA"

Indications:

Adults:

vascular diseases of the brain (dyscirculatory encephalopathy and post-stroke disorders)

the period of convalescence after suffering a traumatic brain injury (TBI)

asthenic and asthenic-depressive disorder, psycho-organic syndrome

relief (in complex therapy) alcohol-withdrawal syndrome

use quality tools to improve processes of memory and attention (intellectually-mnestic functions).

Children 10 years and older:

borderline neuro-psychic disorders of asthenic and neurotic, including the impact of traumatic brain injury (TBI)

comprehensive treatment of mental retardation.

Contraindications:

Increased individual sensitivity to the drug, infectious diseases of CNS, febrile and psychotic condition, blood disease, expressed human liver and kidneys, pregnancy, lactation, age under 10 years.

Side effects:

Allergic reactions, headaches, sleep disturbances, constipation, weight loss, itching, and in some cases of depression (in the elderly).

Drug interactions:

May increase the action of medicines (drugs) that stimulate the Central nervous system.

Method of application and dose:

One teaspoonful of a solution (5 ml) corresponds to 1 g of active substance. Adults the drug is prescribed inside 1 teaspoon 2-3 times daily, last admission no later than 4 hours before bedtime. The maximum single dose 2 g (2 tsp), in special cases, may increase doses by prescription (maximum daily dose 10 g (10 h. spoons).

Therapeutic daily dose in children 10-12 years of age should make 0, 5-1, 0 g (1/2–1 teaspoon) Nooclerin, children over 12 years — 1-2 g (1-2 teaspoons).

The duration of treatment — 1, 5-2 months 2-3 times a year.

Overdose:

In case of overdose happens the symptoms are severe side effects.

First aid — gastric lavage, administration of activated charcoal. If necessary, — symptomatic therapy.

Special instructions:

Data on the effect of the drug on driving vehicles and occupation of other potentially hazardous activities, require high concentration and psychomotor speed reactions, are absent.

Expiration date:

After opening the bottle the drug is stored for 1 month.