Expiration date: 04/2025

Composition

Active substance: fluoxetine, 0.02 g

Excipients: microcrystalline cellulose, colloidal silicon dioxide (Aerosil), magnesium stearate.

Packaging: 20 pc

Pharmachologic effect

PROFLUZAK - selectively blocks the reverse neuronal uptake of serotonin (5HT) in the synapses of neurons of the central nervous system (CNS).

Inhibition of reuptake of serotonin leads to increasing the concentration of the neurotransmitter in the synaptic cleft, amplifies and prolong its effect on post-synaptic receptor sites.

At therapeutic doses fluoxetine blocks the uptake of serotonin human platelets.

He is a weak antagonist of muscarinic, histamine H 1, and adrenergic ? 1 ? 2 receptors, has little effect on the reuptake of dopamine.

It improves mood, reduces the feeling of fear and tension.

Eliminates dysphoria, it causes a decrease in appetite. It does not cause sedation.

It is the reduction of obsessive-compulsive disorders.

When taken in high therapeutic doses, has practically no effect on the function of the cardiovascular and other systems.

Persistent clinical effect occurs within 1 to 2 weeks.

Testimony

• Depression different etiology.
  
• Bulimia Nervosa.
  
• Obsessive-compulsive disorder.
  

Contraindications

• Hypersensitivity to the drug.
  
• Simultaneous treatment with MAO inhibitors.
  
• The period of breastfeeding.
  
• Pregnancy.
  
• Severe renal and hepatic function (creatinine clearance less than 10 ml / min).
  
• Suicidal thoughts.
  

Pregnancy and breast-feeding

It contraindicated use during pregnancy.

Dosing and Administration

The drug is taken orally.

When depression

The initial dose is 20 mg 1 time per day in the first half of the day, regardless of meals.

the dose may be increased if necessary, but not more than 80 mg / day.

When bulimia

The drug is administered in a daily dose of 60 mg, divided into 2-3 doses.

With obsessive-compulsive disorder

20-60 mg / day.

The maintenance dose of 20 mg / day.

The course of treatment - 3-4 weeks.

Use in elderly patients

The recommended daily dose is 20 mg.

Use in patients with impaired liver and kidney function

It recommends the use of lower doses and lengthening the interval between doses.

Overdose

Symptoms: agitation, restlessness, seizures, cardiac arrhythmia, tachycardia, nausea, vomiting.

Treatment: specific antagonists to fluoxetine were found. Symptomatic therapy, gastric lavage with the appointment of activated charcoal, in convulsions - diazepam, maintenance of respiration, cardiac activity, body temperature.

Storage conditions

Store in a dry, dark place at a temperature no higher than 25 ° C.

Shelf life: 2 years