Expiration date: 04/2025
The composition and form of issue:
Tablets. 1 tablet contains acarbose 50 or 100 mg
excipients: silica colloidal anhydrous — 0,25/0,5 mg of magnesium stearate and 0.5/1 mg of corn starch — 54,25/108,5 mg MKC — 30/60 mg
15 PCs in blister, in box 2 or 8 blisters.
Description pharmaceutical form:
50 mg tablets: white or off white to yellowish round biconvex tablets engraved with a proprietary marking (bierowski cross) on one side and dosage "G 50" — on the reverse.
Tablets 100 mg: white or off white to yellowish oblong biconvex tablets with a break-line on both sides, one of them is engraved, indicating the dosage, "G 100".
Pharmacological action:
Inhibits intestinal alpha-glucosidase, which breaks down di-, oligo - and polysaccharides slows down the absorption of carbohydrates (including glucose), reduces the average level and daily fluctuations in blood glucose.
Indications:
Diabetes mellitus I (combination therapy) and type II.
Contraindications:
Hypersensitivity, chronic intestinal diseases with marked disorders of digestion and absorption, roemheld syndrome, major hernias, narrowing and ulcers of the intestine, teenage and youthful age (till 18 years).
Application of pregnancy and breast-feeding:
Contraindicated in pregnancy. Nursing mothers should stop breast-feeding.
Side effects:
Sometimes it is possible to: dyspepsia, increase in liver transaminases.
Drug interactions:
Do gipoglikemiceski effect protivodiabeticakih funds. Antatsida, holestiramin, intestinal adsorbents and digestive enzymes reduce the effect.
Method of application and dose:
Inside, directly before the meal whole, without chewing, with a small amount of fluid or liquid from the first portion of food.
The optimal dose is selected by the attending physician individually for each patient, because efficacy and tolerability vary.
Combination therapy in combination with diet in patients with diabetes mellitus type 2
Initial dose 1 table. 50 mg or 1/2 tab. 100 mg 3 times a day. Further, the dose should be increased to a daily average of 300 mg per day (2 table. 50 mg or 1 tab. 100 mg 3 times a day). If necessary, the dose may be increased to 200 mg 3 times a day.
The dose should be increased with an interval of 4-8 weeks in case the previous dose in patients not obtained the desired clinical effect.
If a patient despite strict adherence to diet, increase flatulence and diarrhea, further dose escalation of the drug should be discontinued, and in some cases reduce.
Prevention of diabetes type 2 in patients with impaired glucose tolerance in combination with diet and exercise
Initial dose 50 mg 1 times / day (1 table. 50 mg or 1/2 tab. 100 mg). Within 3 months, the initial dose is gradually increased to the recommended therapeutic dose of 100 mg 3 times a day ( 2 table. 50 mg or 1 tab. 100 mg).
Elderly patients (over 65 years): dose adjustment is not required.
Children: use is contraindicated.
Hepatic failure: dose adjustment is not required.
