Expiration date: 03/2025

The composition and form of issue:

Lyophilisate for preparation of solution for injections and local application of 1 amp. or FL.

trypsin (pancreas of cattle) 10 mg

in vials of 10 mg, complete with a knife ampulnam, in a cardboard bundle 10 sets or in vials of 10 mg in a cardboard bundle 10 vials.

Feature:

Endogenous proteolytic enzyme.

Description pharmacological action:

Optimum action at pH 7-9. The local application has anti-inflammatory, regenerating and necrolytic effect. Storage nekrotizirovannye tissue and fibrotic formation, promotes rejection of necrotic tissue, the pus liquefies and facilitates its separation, improves the process of regeneration of wounds. Does not cause changes in the hemostatic system. In relation to healthy tissue is inactive and safe in connection with the presence of trypsin inhibitors (specific and nonspecific).

Dosage:

Dosage form:

Lyophilisate for preparation of solution for injections and local application, lyophilisate for preparation of solution for local and external use, medical wipes

Pharmacological action:

Endogenous proteolytic enzyme. Optimum action at pH 7-9. The local application has anti-inflammatory, antimicrobial, regenerative and necrolytic effect. Nekrotizirovannye breaks down tissue and fibrotic formation, promotes rejection of necrotic tissue, the pus liquefies and facilitates its separation, improves the process of regeneration of wounds. Does not cause changes in the hemostatic system. In relation to healthy tissue is inactive and safe in connection with the presence of trypsin inhibitors (specific and nonspecific).

Indications:

Diseases of the respiratory tract, empyema, pleural effusion, thrombophlebitis, periodontal disease (inflammatory-dystrophic form), osteomyelitis, sinusitis, otitis, iritis, iridocyclitis, hemorrhage in the anterior chamber of the eye, swelling of the periorbital region after operations and injuries, burns, bedsores, sores (applied topically).

Contraindications:

Hypersensitivity, decompensated CHF, pulmonary emphysema with respiratory failure, decompensated forms of pulmonary tuberculosis, liver degeneration, liver cirrhosis, pancreatitis, infectious hepatitis, hemorrhagic diathesis. Cannot be inserted into the bleeding cavity, I/, applied to the ulcerated surface of cancer.

Side effects:

Allergic reactions, hyperthermia, tachycardia. When the/m introduction - soreness, redness at the injection site, introduction of the inhalation - irritation of mucous membranes of the upper respiratory tract, hoarseness.

Method of application and dose:

V/m: adults - 5-10 mg 1-2 times a day children - 2.5 mg 1 times a day. For injection immediately before use, diluted 5 mg of crystalline trypsin in 1-2 ml 0.9% NaCl solution or 0.5-2% solution of procaine. The course of treatment - 6-15 injections. Also used electrophoresis with trypsin: 1 the procedure 10 mg of trypsin (dissolved in 15-20 ml of distilled water) injected with the negative pole. Inhalation: 5-10 mg in 2-3 ml 0.9% NaCl via nebulizer or via a bronchoscope. After inhalation, rinse your mouth with warm water and washed his nose. Eye drops: 0.2-0.25% solution that is prepared immediately before use. Intraplevralno: 1 times a day, 10-20 mg, dissolved in 20-50 ml 0.9% solution of NaCl. Locally: in the form of powder or of a solution of trypsin amorphous, dry or nekrotizirovannye wounds impose compresses (solution prepared immediately before use: 50 mg trypsin dissolved in 5 ml of sterile water or 0.9% NaCl solution, in the treatment of purulent wounds - in 5 ml phosphate buffer solution). Intraplevralno: 50-150 mg per 5-30 ml of phosphate buffer solution, preferably after the introduction of the frequent changing of body position on day 2 after instillation, produced, usually, the liquefied exudate. Three-layer woven fabric made of dialdehydecellulose impregnated with trypsin, impose on the wound (after processing) and fixed with a bandage, leave on the wound for more than 24 h Before use a cloth moistened with distilled water or solution furatsilina. The time of complete wound cleansing from necrotic tissue and pus - 24-72 h. If necessary, apply again.

The description of the drug Trypsin is not intended to assign treatment without a doctor.

Indications:

• diseases of the respiratory tract
  
• empyema
  
• exudative pleurisy
  
• thrombophlebitis
  
• periodontal disease (inflammatory-dystrophic form)
  
• osteomyelitis
  
• sinusitis
  
• otitis
  
• irit
  
• iridocyclitis
  
• hemorrhage in the anterior chamber of the eye
  
• edema of the periorbital area after operations and injuries
  
• burns, bedsores, sores (applied topically).
  

Contraindications:

• hypersensitivity
  
• decompensated chronic heart failure
  
• emphysema with respiratory failure
  
• decompensated forms of pulmonary tuberculosis
  
• liver
  
• cirrhosis of the liver
  
• pancreatitis
  
• infectious hepatitis
  
• hemorrhagic diathesis
  
• in/in the introduction in a bleeding cavity applying to the ulcerated surface of cancer.
  

Side effects:

Allergic reactions, hyperthermia, tachycardia. When the/m introduction — soreness, redness at the injection site, introduction of the inhalation — irritation of mucous membranes of the upper respiratory tract, hoarseness.

Method of application and dose:

In/m. Adults: 5-10 mg 1-2 times daily children — 2, 5 mg 1 time per day. For injection immediately before use, diluted 5 mg of crystalline trypsin in 1-2 ml of 0 9% NaCl or 0, 5-2% solution of procaine. The course of treatment — 6-15 injections. Also used electrophoresis with trypsin: 1 the procedure 10 mg of trypsin (dissolved in 15-20 ml of distilled water) injected with the negative pole.

Inhalation: 5-10 mg 2-3 ml 0, 9% NaCl via nebulizer or via a bronchoscope. After inhalation, rinse your mouth with warm water and washed his nose.

Eye drops: kongungualno, 0, 2-0, 25% solution, which is prepared immediately before use.

Intraplevralno: 1 times a day, 10-20 mg, dissolved in 20-50 ml 0, 9% NaCl solution.

Intraplevralno: 50-150 mg per 5-30 ml of phosphate buffer solution, preferably after the introduction of frequent changes of position on the 2nd day after instillation, produced, usually, the liquefied exudate.

Local:three-layer fabric from dialdehydecellulose impregnated with a solution of trypsin, impose on the wound (after processing) and fixed with a bandage, leave on the wound for more than 24 h Before use a cloth moistened with distilled water or solution furatsilina. The time of complete wound cleansing from necrotic tissue and pus — 24-72 h. If necessary, apply again.