Expiration date: 12/2025

The composition and form of issue:

1 ml of solution contains dorzolamide hydrochloride 20 mg in vials, 5 ml, box 1 vial.

Pharmacological action:

Inhibits carbonic anhydrase in the ciliary body of the eye, reduces the secretion of intraocular fluid.

Pharmacokinetics:

Partially absorbed on the mucous membranes of the eye. Write mainly kidneys, including in the form of metabolites.

Description pharmacological action:

It has a predominantly local action, absorption can cause systemic effects characteristic of sulfonamides (e.g. a diuretic).

Clinical pharmacology:

Efficacy and safety not depend on the age (including patients older than 65-75 years). However, you should consider the possibility of greater sensitivity to the drug in some older patients.

Indications:

Elevated intraocular pressure, primary and secondary (including pseudoexfoliative) open-angle glaucoma.

Contraindications:

Hypersensitivity, severe renal insufficiency (Cl creatinine 30 ml/min or less), children's age.

Application of pregnancy and breast-feeding:

Perhaps, if the expected therapeutic effect for the mother justifies the potential risk to the fetus. Appointment lactation requires the suspension of breastfeeding.

Side effects:

Burning, tingling and itching in the eyes, irritation of the eyelids, blurred vision, lacrimation, conjunctivitis, blepharitis, iridocyclitis, bitter taste in the mouth, nausea, headache, asthenia, fatigue, rash, nefrourolitiaz.

Drug interactions:

Working with ophthalmic solutions of timolol and betaxolol. May be combined with ACE inhibitors, calcium antagonists, diuretics, NSAIDs (including aspirin), estrogen, insulin, thyroxine, although not excluded increase toxicity (for example, when high doses of aspirin).

Method of application and dose:

Kongungualno, 1 drop 3 times per day. In combination with beta-blockers — 1 drop 2 times a day. In conjunction with several local ophthalmic drugs introduction of each of them is carried out with an interval of 10 min.

Overdose:

Causes electrolyte imbalance, acidosis, disorders of the Central nervous system. Treatment is symptomatic. It is necessary to control the level of serum electrolytes (especially potassium) and blood pH.

Precautions:

Be wary appoint patients with impaired liver function, if you are wearing contact lenses (possible absorption of benzalkonium chloride preservative, a member of the drug).