Expiration date: 01/2025
The composition and form of issue:
Capsules. 1 capsule contains:
unithiol (2,3-dimercaprol sodium) 150, 250 mg
calcium Pantothenate 7, 10 mg
other ingredients: microcrystalline cellulose citric acid starch 1500 magnesium hydrogen phosphate (magnesium phosphate disodium) povidone silica colloidal anhydrous
hard gelatin capsule: gelatin titanium dioxide azorubine Ponceau 4R
in a contour acheikova package 5 PCs. or 2 (for capsules 250 mg + 10 mg) or 10 PCs (for capsules 150 mg + 7 mg) in cardboard pack 1 (or 2 or 10 PCs) or 2 packages (5 pieces).
Description pharmaceutical form:
Capsules for dosage 150 mg + 7 mg capsule 0 — for dosage 250 mg + 10 mg, the body — white lid — pink.
The contents of capsules — granules and powder white with kremovatym, prone to clumping.
Allowed the presence of a weak peculiar smell.
Pharmacokinetics:
After intake of capsules containing 250 mg of unithiol, Cmax levels achieved after 1.5 hours and is within 90-140 mg/l. the Average residence time of drug in the body 9-11 h — (10,16±0.39 in) h, including in the gastrointestinal tract is 15-20 min. T1/2 — (7,5±0,46) h. Calcium Pantothenate is well absorbed in the intestine and is cleaved, releasing Pantothenic acid, which participates in carbohydrate and fat metabolism, stimulates the formation of corticosteroids, accelerates regeneration processes. About 60% of the drug excreted in the urine, and partly with faeces.
Description pharmacological action:
Provides detoxification (including in relation to the products the half-life of ethanol, heavy metals and their compounds, arsenic compounds). Clinical studies have shown hepatoprotective and antioxidant properties of unithiol.
The active sulfhydryl group of unithiol, interacting with thiol poisons, and products of the half-life of alcohol (ethanol) in blood and tissues, forming with them non-toxic compounds (complexes), which are excreted in the urine.
While taking the drug inside unitiol with portal blood enters the liver, where rapid and physiologically irreversibly binds to acetaldehyde. Zoreks activates the alcohol dehydrogenase, strengthening the process of ethanol oxidation and the detoxification of its toxic agents enzyme system of the liver. The presence of the drug zoreks of Pantothenate calcium enhances the detoxification effect of unithiol.
Indications:
- alcohol abuse
- alcohol withdrawal syndrome
- chronic alcoholism (in the complex therapy)
- acute and chronic poisoning organic and inorganic arsenic compounds, mercury, gold, chromium, cadmium, cobalt, copper, zinc, Nickel, bismuth, antimony
- intoxication cardiac glycosides.
Contraindications:
- hypersensitivity to the drug
- severe decompensated diseases of the liver and kidneys.
- Caution: lower AD.
Application of pregnancy and breast-feeding:
Data on the use of drugs during pregnancy and breastfeeding is not.
Side effects:
Rarely, allergic reactions when used in high doses: nausea, dizziness, tachycardia, pallor.
Drug interactions:
Incompatible with drugs containing salts of heavy metals as well as alkalis (quickly broken).
Method of application and dose:
Inside, 30 minutes before a meal, not liquid, squeezed water.
If abuse of alcohol or alcohol withdrawal syndrome, 1 capsule. (250 mg + 10 mg), 1-2 times a day. If necessary, the daily dose can be increased up to 1000 mg, and the reception frequency to increase to 3 times a day. The drug should be taken 3-7 days, until the cessation of symptoms of intoxication.
In chronic alcoholism, and 1 caps. (150 mg + 7 mg) 1-2 times a day for 10 days.
In cases of poisoning by arsenic compounds and heavy metal salts — 300-1000 mg/day, divided into 2-3 doses, for 7-10 days.
Overdose:
Symptoms of overdose may appear if you exceed the recommended dose more than 10 times.
Symptoms: shortness of breath, hyperkinesis, lethargy, drowsiness, stupor, intermittent seizures.
Treatment: gastric lavage, the appointment activated charcoal, laxatives, symptomatic therapy, in acute cases, oxygen therapy, the introduction of dextrose, etc.
