Expiration date: 11/2025

Composition and form of release:

Lyophilizate for the preparation of a solution for intranasal administration of 1 fl.

active substance:

interferon gamma 100 thousand. ME (5, 5±0, 5)

excipients: mannitol

in vials in a pack of cardboard 1 or 5 vials (complete with water for injection of 5 ml in a bottle or ampoule).

Description of the dosage form:

loose or porous mass of white color, hygroscopic.

Description of pharmacological action:

Ingarone is a recombinant human interferon gamma, consisting of 144 amino acid residues (a.o.), devoid of the first three a.o. - Cys-Tyr-Cys, replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on cells (human fibroblasts) infected with vesicular stomatitis virus is 2 * 10 7 U / mg of protein. Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine, the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Interferon gamma receptors have macrophages, neutrophils, natural killer cells, and cytotoxic T-lymphocytes. Interferon gamma activates the effector functions of these cells, in particular their microbocidicity, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals, thereby causing the death of intracellular parasites. Interferon gamma inhibits the B-cell response, IL-4, and inhibits IgE production and CD23-antigen expression. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. Cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and generation of lymphokine-activated killers. Activates the production of proteins of the acute phase of inflammation, increases the expression of genes C2 and C4 components of the complement system.

Unlike other interferons, it increases the expression of antigens of the main histocompatibility complex (HCGS) of both classes 1 and 2 on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of antigen presentation and the ability of T-lymphocytes to recognize them.

Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins, and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.

Interferon gamma blocks the synthesis of beta-TGF, which is responsible for the development of lung and liver fibrosis.

Indications:

Complex therapy for the prevention and treatment of influenza and avian influenza (H5N1 and H1N1).

Contraindications:

children under 7 years of age.

Use during pregnancy and lactation:

Contraindicated in pregnancy.

Side effect:

not noted.

Method of administration and dosage:

The intranasal route. The contents of the vial are dissolved in 5 ml of water for injection.

At the first signs of influenza, ARVI-2 drops in each nasal passage, after the toilet of the nasal passages, 5 times a day for 5-7 days.

For the prevention of SARS and influenza in contact with the patient and / or hypothermia-2-3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days. If necessary, the preventive courses are repeated. With a single contact, one instillation is sufficient.

After instillation, it is recommended to massage the wings of the nose with your fingers for a few minutes to evenly distribute the drug in the nasal cavity.

Storage conditions:

Do not freeze.