Expiration date: 11/2025
Structure and Composition:
1 tablet contains 2 mg estriol in a blister pack of 30 pieces, in a cardboard bundle one blister.
1 g of cream vaginal - 1 mg in tubes of 15 grams complete with an applicator, in a cardboard bundle one package.
1 vaginal suppository - 0.5 mg in blister 5 pieces in a carton box 3 blisters..
Pharmachologic effect:
Restores the vaginal epithelium, the medium helps to normalize pH and microflora in the vagina, thereby enhancing vaginal epithelial resistance to infectious and inflammatory processes.
Pharmacokinetics:
When applied topically inside and rapidly and almost completely absorbed. Cmax is achieved within 1 h after oral administration and after 2.1 hours at intravaginal application. Write mainly kidneys in conjugated form, 2% is excreted through the intestine unchanged.
Description of the pharmacological actions:
Since estriol interacts with the nuclei of endometrial cells in a short time, taking in the recommended doses does not cause endometrial proliferation and does not require additional therapy progestogens (there is no withdrawal bleeding).
Testimony:
Atrophy of the mucosa of the lower genital tract, caused by estrogen deficiency: dryness and itching in the vagina, pain during sexual intercourse, frequent painful urination, chronic cystitis, urinary incontinence with urge pre- and postoperative therapy in post-menopausal women at operative vaginal access unknown of cervical cytological study (suspected neoplastic process) against atrophic changes (for diagnostic purposes).
Contraindications:
Hypersensitivity, estrogen dependent tumors (diagnosed or suspected), vaginal bleeding of unknown etiology thrombosis (venous and arterial), including: in history, pregnancy.
Application of pregnancy and breastfeeding:
Contraindicated during pregnancy.
Side effect:
Tension or breast tenderness, nausea, alopecia pigmentation, hypersecretion of cervical mucus, rarely - headache, hypertension, leg cramps, blurred vision, local irritation or itching (cream).
Dosage and administration:
Tablets: inwards daily 4 mg 1 time per day for 3 weeks, then - the gradual reduction of the dose to 2 mg per week.
Cream: intravaginally, 1 dose (using a calibrated applicator) daily at bedtime for 3 weeks, then - the gradual reduction of the dose to 1 administration per week.
Suppositories: vaginally, 1 supp. daily at bedtime for 3 weeks, then - the gradual reduction of the dose to 1 supp. in Week.
Precautionary measures:
It is recommended careful monitoring of the patients with thromboembolic disease in history, severe renal impairment, porphyria, severe itching symptoms or cholestatic jaundice during pregnancy or previous admission of steroid medications, pregnant herpes, otosclerosis.
Special instructions:
When receiving Ovestin recommended annual medical examination.
