Expiration date: 04/2025
The composition and form of issue:
Eye drops, 1 ml contains:
tobramycin 3 mg
dexamethasone 1 mg
auxiliary substances: benzalkonium chloride, disodium edetate, sodium chloride, sodium sulfate anhydrous, tyloxapol, hydroxyethyl cellulose, sulphuric acid and/or sodium hydroxide (to bring the pH), purified water
in vials of 5 ml (dispenser "Drop Tainer™"), the paper cartons 1 a bottle.
Description pharmaceutical form:
Eye drops: suspension from white to almost white.
Pharmacokinetics:
The local application of systemic absorption is low.
Description pharmacological action:
A combination drug.
Tobramycin is an antibiotic of the aminoglycoside produced by Streptococcus tenebrarius has a broad spectrum of antibacterial action, active against gram-positive and gram-negative microorganisms: Staphylococcus (including Staphylococcus aureus, Staphylococcus epidermidis), including strains resistant to penicillin streptococci, including some beta-hemolytic species of the group And, newemailusecase species, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris species, Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species.
Dexamethasone corticosteroids. Anti-inflammatory, antiallergic and desensitizing effect. Has antiexudative effect. Dexamethasone actively suppresses inflammation.
The combination of corticosteroids with an antibiotic (tobramycin) to reduce the risk of infection.
Indications:
- prevention of postoperative infections
- blepharitis
- conjunctivitis
- keratitis (without damage of the epithelium).
Contraindications:
- individual hypersensitivity to the drug
- viral diseases of the cornea and conjunctiva (including keratitis caused by Herpes simplex, varicella)
- mycobacterial infection of the eye
- fungal diseases of the eye
- condition after removal of the foreign body of the cornea.
Application of pregnancy and breast-feeding:
Sufficient experience in use of the drug during pregnancy, breast-feeding is not. Perhaps the use for the treatment of pregnant women prescribed by a doctor, if the expected therapeutic effect exceeds the risk of possible side effects. Discontinue use of the drug on the breast-feeding period.
Side effects:
Hypersensitivity and allergic reactions (itching, swelling of eyelids, conjunctival hyperemia).
Side effects due to the steroid component are: increased intraocular pressure rear subcapsular cataracts, slow the healing process.
The secondary infection. The development of secondary infection has been observed after the use of combined preparations containing corticosteroids in combination with antibiotics. Fungal infections in the cornea tend to occur particularly often with long-term use of steroids. Appearance on corneal nonhealing ulcers after long-term treatment with steroid medications may indicate the development of a fungal infestation. Secondary bacterial infection may occur as a consequence of the suppression of defence reactions of the body of the patient.
Drug interactions:
In the case of use with other topical ophthalmic drugs the interval between their application shall not be less than 5 min.
In the case of appointment of tobramycin topically simultaneously with systemic aminoglycoside antibiotics, should monitor the overall blood picture.
Method of application and dose:
Into the conjunctival SAC.
Eye drops: 1-2 drops every 4-6 h In the first 24-48 hours, the dose may be increased to 1-2 drops every 2 hours.
Overdose:
Symptoms: irritation of the mucous membranes of the eyes, itching, tearing, swelling of eyelids, conjunctival hyperemia.
Treatment: rinsing with warm water, treatment is symptomatic.
Special instructions:
The bottle must be closed after each use.
Do not touch the tip of the pipette to the eye.
Vial-dropper "Droptimer" with eye drops shake well before use, store in a vertical position.
