Expiration date: 08/2025
The composition and form of issue:
Lyophilisate for preparation of solution for injection. 1 vial contains:
methylprednisolone (as sodium succinate) 500 or 1000 mg
excipients: monobasic monohydrate sodium phosphate, secondary acid phosphate sodium
solvent: benzyl alcohol — 9 mg water for injection — q.s. 1 ml
in the paper cartons 1 a bottle complete with the solvent in vials.
Lyophilisate for preparation of solution for injection. 1 vial contains:
methylprednisolone (as sodium succinate) 40 mg
auxiliary substances: lactose monohydrate monobasic sodium phosphate, secondary acid phosphate sodium
in the paper cartons 1 a bottle two-cells Act?0-Vial.
Lyophilisate for preparation of solution for injection. 1 vial contains:
methylprednisolone (as sodium succinate) 125 or 250 mg
excipients: monobasic monohydrate sodium phosphate, secondary acid phosphate sodium
in the paper cartons 1 a bottle two-cells Act?0-Vial.
Method of application and dose:
In/in, in/m or in/in infusion, but in case of emergency, treatment is initiated with intravenous injection. Children should be administered a lower dose (but not less than 0.5 mg/kg/day), however, when the dose first consider the severity of the condition and the patient's response to therapy, but not age and body weight.
As adjunctive therapy in life-threatening conditions, in/in, 30 mg/kg over at least 30 min. Introduction can be repeated every 4-6 h for 48 h
Pulse therapy in the treatment of diseases in which effective corticosteroid therapy in exacerbations of the disease and/or ineffectiveness of standard therapy. We recommend the following regimens:
| Rheumatic diseases | 1 g/day/V for 1-4 days or 1 g per month/for 6 months |
| Systemic lupus erythematosus | 1 g/day/for 3 days |
| Multiple sclerosis | 1 g/day/for 3 or 5 days |
| Edematous States, e.g., glomerulonephritis, lupus nephritis | 30 mg/kg/a day for 4 days or 1 g/day/for 3, 5 or 7 days |
The above doses should be administered for at least 30 min. Introduction can be repeated, if within 1 month after the treatment has not come improvement, or required by the patient's condition.
Cancer in the terminal stage — to improve the quality of life in 125 mg/day daily for up to 8 weeks.
Prevention of nausea and vomiting associated with chemotherapy for cancer diseases. During chemotherapy, characterized by small or srednevyrazhennymi gag effect, in 250 mg for at least 5 min for 1 h before the administration of chemotherapy, at the beginning and after the end of the introduction. To enhance the effect with the first dose of the drug solu-Medrol you can enter the drugs chlorophenothiazine.
During chemotherapy, characterized by a strong gag effect, in 250 mg for at least 5 minutes in combination with appropriate doses of metoclopramide or a butyrophenone 1 hour before the administration of chemotherapy, then in/to 250 mg in the beginning and after the end of the introduction.
Acute traumatic injuries of the spinal cord. Treatment should start in the first 8 hours after injury. Recommended in/bolusnoe in a dose of 30 mg/kg over 15 minutes, then after a 45-minute interval for continuous infusion in a dose of 5.4 mg/kg/h for 23 h. the Drug should be administered using the infusion pump in an isolated vein.
In other indications initial dose of 10-500 mg in/in, depending on the nature of the disease. For a short course in severe acute conditions may require higher doses. Initial dose not exceeding 250 mg, should be entered in/for a period of not less than 5 min, a dose of 250 mg at least 30 min. Subsequent dose is injected in/in or/m, while the length of intervals between doses depends on the patient's response to therapy and clinical status.
Preparation of solutions.
Preparations for parenteral administration should be inspected visually for changes in color or appearance of particles.
a) Two-cells the bottle Act?0-Vial:
1. Click on plastic activator to the solvent poured into the lower container.
2. Gently shake the bottle until until the powder is dissolved.
3. Remove the plastic disk covering the centre of the tube.
4. To treat the tube surface with the appropriate antiseptic.
5. Puncturing needle tube center so that I could see the tip of the needle. Turn the bottle and syringe to take the required amount of solution.
b) Vial.
In observance of asepsis inject the solvent into the vial of lyophilisate. Use only the recommended solvent.
C) Preparation of solutions for I/V infusion.
To prepare a solution as described above. The drug can also be introduced in the form of diluted solution obtained by mixing the initial solution of the drug with 5% aqueous dextrose solution, physiological saline, 5% dextrose solution with 0.45% or 0.9% solution of sodium chloride. The prepared solutions are physically and chemically stable for 48 hours.
Expiration date:
The solution is ready for use within 48 h after preparation.
