Expiration date: 06/2025

Active substance: The polypeptides of the cerebral cortex of cattle. 

Pharmachologic effect

Mode of action - tissue-specific, neuroprotective, nootropic, antioxidant.

Pharmacodynamics

Cortexin® contains a complex of low-molecular weight water-soluble polypeptide fractions of penetrating the BBB directly to the nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific action.

Nootropic - enhances higher brain function, learning and memory processes, concentration, stability under various stress conditions.

Neuroprotective - protects neurons from neurotoxic injury various endogenous factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant - inhibits lipid peroxidation in neurons increases neuronal survival in conditions of oxidative stress and hypoxia.

Tissue-specific - activates the metabolism of CNS neurons and peripheral nervous system, repair processes, improves function of the cerebral cortex and the overall tone of the nervous system.

The mechanism of action Cortexin® caused by activation of neurons of the brain peptides and neurotrophic factors; optimizing the balance of excitatory and inhibitory metabolism of amino acids, dopamine, serotonin; GABAergic influence; decrease in the level of paroxysmal convulsive brain activity, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).

Pharmacokinetics

Composition Cortexin®, whose active ingredient is a complex of polypeptide fractions, does not allow for the usual pharmacokinetic analysis of the individual components.

Testimony

In the treatment of:

• cerebrovascular accident;
  
• TBI and its effects;
  
• encephalopathies of various origins;
  
• cognitive disorders (disorders of memory and thinking);
  
• acute and chronic encephalitis and encephalomyelitis;
  
• epilepsy;
  
• asthenic conditions (suprasegmental autonomic dysfunction);
  
• a reduced ability to learn;
  
• delayed psychomotor and speech development in children;
  
• various forms of cerebral palsy.
  

Contraindications

Individual intolerance to the drug.

Pregnancy and breast-feeding

The drug is contraindicated during pregnancy (due to lack of clinical data). If necessary, the appointment during lactation should stop breastfeeding (because of the lack of clinical data).

Side effects

Data on adverse effects were reported.

The individual hypersensitivity to the drug.

Interaction

Drug interactions of the drug has not been described.

Dosing and Administration

The drug is administered intramuscularly.

The contents of the vial prior to injection were dissolved in 1.2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution by guiding the needle to the wall of the vial to avoid foaming, and is administered once daily: adult dose of 10 mg for 10 days; children with body weight 20 kg - 0.5 mg / kg body weight over 20 kg - 10 mg for 10 days.

If necessary, a second course of 3-6 months.

At the hemispheric ischemic stroke in the acute and early recovery periods adult dose of 10 mg 2 times a day (morning and afternoon) for 10 days, with a repeated course in 10 days.

Overdose

Currently, the cases of overdose have been reported.

Manufacturer

"Geropharm" LLC. 191144, Russia, Saint-Petersburg, Tar lane., 11, lit.. B.

Storage conditions

In the dark place at a temperature of 2-20 ° C.

Keep out of the reach of children.

The shelf life: 3 years.

Do not use beyond the expiration date printed on the package.