Expiration date: 08/2025

Indications

Prevention of unwanted pregnancy

release Form

pills Levonorgestrel 150 mcg + Ethinylestradiol 30 mcg, 21 blister, carton pack 1,

pharmacodynamics

Progestogen contraceptive, the pharmacologically active isomer of norgestrel. It affects the gonadotropic pituitary function, which leads to a slight decrease in FSH and LH peak. It causes changes in the endometrium, which is likely to disrupt the process of implantation of the egg. It helps increase the viscosity of the cervical mucus, which hinders the promotion of sperm.

Levonorgestrel 2 times stronger than norgestrel.

Pharmacokinetics

Once inside quickly and completely absorbed from the gastrointestinal tract. In a small extent metabolized in the "first pass" through the liver. Plasma protein binding is high. It is metabolized in the liver with the formation of sulfate and glucuronide conjugates, which are excreted in the urine and to a lesser extent - through the intestines.

Use during pregnancy

Contraindicated during pregnancy.

Levonorgestrel is excreted in breast milk in small amounts, so use during lactation is not recommended.

Contraindications

Pregnancy or suspected malignancy of genital organs and breast, uterine bleeding unclear etiology, acute liver disease, liver cancer, thromboembolic disorders, thrombophlebitis, cerebrovascular disease, coronary artery disease, hypersensitivity to levonorgestrel.

Side effects

In some cases - menstrual disorders (frequent and / or irregular bleeding, amenorrhea), breast tenderness, headache, dizziness, nausea, vomiting, diarrhea, skin lesions (including acne and hirsutism), change in body weight and libido, depression, vaginal secretion change, deterioration tolerability of contact lenses, allergic reactions.

Dosing and Administration

Inside.

When and how to take pills

Blister contains 21 pills. Each pellet is marked by day of the week in which it must be taken.

Taking pills to be every day at the same time, with a little water. It is necessary to follow the direction of the arrow, until all 21 pills are not taken. For the next 7 days - a break from taking the drug. Menstruation (withdrawal bleeding) should begin during these 7 days. Usually it begins 2-3 days after the last pellet.

After a 7-day interval (on day 8) begin reception of the next pack dragees, even if bleeding has not yet ceased. This means that you should always start a new pack in the same day of the week and every month withdrawal bleeding will advance approximately one and the same day of the week.

Receiving the first package Microgynon®

As in the previous month no hormonal contraceptive has not been used

Start receiving Microgynon® in the 1 st day of the cycle, ie, in the 1 st day of menstrual bleeding. Take the pills, which marked the corresponding day of the week. Then take the pills in order. You can also start taking on 2-5 days of the menstrual cycle, but in this case it is necessary to use an additional barrier method of contraception during the first 7 days of tablet-taking from the first package.

When switching from other combined oral contraceptive

Admission Microgynon® can start the next day after taking the last tablet of the current package of combined oral contraceptives (ie without a tablet-free interval). If the current package contains 28 tab. You can start taking Microgynon® the next day after taking the last active tablet. If a woman is not sure that it is a tablet, it should ask the doctor. You can also start taking later, but in any case not later than the day after the usual break in reception (for products containing Table 21.) Or after the last inactive tablet (for products containing Table 28. In the package).

When switching from oral contraceptives containing only progestogen ( "mini-pill")

You can stop taking the "mini-pill" in any day and start taking Microgynon® the next day, at the same time. During the first 7 days of tablet-taking must also use an additional barrier method of contraception.

When switching from a contraceptive injection or implant

It should start taking Microgynon® the day when the next injection or daily removal of the implant must be made. During the first 7 days of tablet-taking must also use an additional barrier method of contraception.

After childbirth

If a woman has just had a baby, your doctor may recommend she wait until after the first normal menstrual cycle before you start receiving Microgynon®. Sometimes, on the advice of a doctor may start taking the drug before.

After a miscarriage or an abortion

It is necessary to consult a doctor.

Admission missed pills

If the delay in taking the next pellet in less than 12 hours, the contraceptive effect Microgynon® saved. Take the pills should be as soon as possible. Next take the pills at the usual time.

If the delay in taking pills made more than 12 hours, contraceptive protection may be reduced. The more pills missed in a row, and the closer this pass to the beginning or the end of the reception, the higher the risk of pregnancy.

It is possible to be guided by the following rules:

Forgotten more than one pellet of the packaging

It is necessary to consult a doctor.

One missed pills in the first week of taking the drug

Take the missed pills as soon as possible (even if this means taking two pills at once). Next take the pills at the usual time. Additionally, you should use a barrier method of contraception for the next 7 days. If intercourse took place during the week before skipping pills, you need to take into account the chance of pregnancy. It is necessary to consult a doctor immediately.

One pills missed during the second week of taking the drug

It should take the missed pills as soon as possible (even if this means taking two pills at once). Next take the pills at the usual time. Contraceptive effect Microgynon® saved and there is no need to use additional contraceptive measures.

One missed pills in the third week of the drug

You can stick to any one of the following two methods to use additional contraception without the need for:

1. Take the missed pills as soon as possible (even if this means taking two pills at once). Next take the pills at the usual time. Start receiving from the next pack immediately after taking the pills from the current package, so there will be a break between packs. Withdrawal bleeding is unlikely until the end of the second package of the pills, but may experience spotting or breakthrough bleeding during the tablet-taking.

2. Stop taking pills from the current package, make a break for 7 days or less (including the day of skipping pills) and then start taking pills from a new package.

Using this scheme, a woman can always start taking the next pack on the day of the week, when it usually does.

If, after taking a break in pills is not expected menses, pregnancy is possible. It is necessary to consult with your doctor before you start taking a new package.

Recommendations in case of vomiting and diarrhea

If a woman has had vomiting or diarrhea (diarrhea) in the range of 3 to 4 hours after taking the pill Microgynon®, the active substance may not completely suck. This situation is similar to missed doses. Therefore, instructions should be followed for missed pills.

Delaying the onset of menstruation

You can delay the onset of menstruation, if you start taking the next pack Microgynon® immediately after the end of the current package. The woman may continue to receive pellets from this packaging so long as he wishes, or for as long as the packing is completed. If a woman wants to start menstruation should stop taking the pills. During the reception Microgynon® of the second package may experience spotting or breakthrough bleeding during the tablet-taking. The next pack should be started after the usual 7-day break.

Changing the date of the onset of menstruation

If a woman takes pills in accordance with the recommendations, it will have menstruation at about the same day every 4 weeks. If changing the menstrual cycle should be shortened (not extend) period of time, free from taking pills. For example, if the menstrual cycle usually starts on a Friday and in future it is necessary that it began on Tuesday (3 days earlier), following the package to start on 3 days earlier than usual. If free of tablet break will be very short (eg 3 days or less), menstruation during the break can not come. In this case, there may be a break-through bleeding or spotting during the days of tablet-taking from the next pack.

Interactions with other drugs

In an application with rifampicin, phenytoin, primidone, barbiturates decreased contraceptive efficacy of levonorgestrel due to increased metabolism of steroids, due to induction of microsomal liver enzymes.

With simultaneous use of ampicillin, sulfamethoxypyridazine, chloramphenicol, nitrofurantoin, fenoksimetipenitsillinom and neomycin may be increased intermenstrual bleeding. This is due to inhibition of the enterohepatic recirculation of sex steroids, which is associated with changes in the intestinal flora.

Levonorgestrel can reduce the effectiveness of oral anticoagulants, antihypertensives, anticonvulsants, and hypoglycemic agents.

Levonorgestrel may interfere with the processes of oxidative metabolism of diazepam and chlordiazepoxide, which leads to the accumulation in the last plasma.

Cautions when receiving

Patients who are overweight, the contraceptive effect of levonorgestrel less effective.

When subcutaneous implantation in patients with acute and severe chronic liver diseases liver function tests should be carried out with an interval of 8-12 weeks.

If the background of levonorgestrel expected menstruation has not occurred within 6 weeks. from the beginning of the last menstrual period or menstrualnopodobnoe reaction, it is necessary to exclude the presence of pregnancy.

With long and persistent intermenstrual bleeding requires additional examination to verify the diagnosis.

Storage conditions

List B .: The temperature is not above 30 ° C.

Shelf life

60 months.