Expiration date: 07/2025

Composition and form of issue:

Tablets prolonged action, film-coated. 1 tablet contains:

dry extract of horse chestnut fruit (Aesculus hippocastanum) 4, 5-5, 5 :1 (extractant — 50% ethanol) 263, 2 mg

content of triterpene glycosides (in terms of escin anhydrous) 50 mg

excipients: calcium hydrogen phosphate anhydrous, silicon dioxide colloidal Eudragit RL 30 D is a copolymer of poly-(ethylacrylate: methyl acrylate: trimetilammoniietilakrilata chloride) 1:2:0, 2 sorbic acid Eudragit RS 30 D is a copolymer of poly-(ethylacrylate: methyl acrylate: trimetilammoniietilakrilata chloride) 1:2:0, 1 sorbic acid triethylcitrate Polysorbate 80 povidone K25 crospovidone magnesium stearate hypromellose (5 mPas) macrogol 4000 iron oxide red (E172) iron oxide yellow (E172) titanium dioxide talc sodium saccharin vanillin penogasashchuu emulsion 

in blister packs of 20 or 25 PCs per pack 1 carton (20 pieces) or 2 or 4 (25 PCs) blister.

Description of dosage form:

Round, biconvex tablets, light brown color.

On the fracture: the shell is light brown and the core is from brown to light brown.

Characteristic:

Medicinal product of plant origin.

Description of pharmacological action:

Reduces capillary permeability, has venotonic, anti-edema, anti-inflammatory and angioprotective action.

Prevents activation of lysosomal enzymes, cleaves proteoglycan, increases the tone of the venous wall, eliminates venous stagnation, reduces the permeability and fragility of capillaries.

It reduces exudation, reduces the effusion of fluid in the tissue and accelerates the resorption of existing edema.

Inhibits inflammation, improves microcirculation, promotes repair of organs and tissues.

Dosage:

Efficacy and safety in childhood has not been studied, so

the use of the drug in childhood is not recommended.

Attention! All additional requirements must be strictly adhered to

doctor, such as: bandaging of the legs, wearing elastic stockings, leg cold

tubs. All requirements must be strictly observed!

In case of sudden appearance of severe symptoms (especially on one

foot), such as: strong swelling, skin color change, feeling

tension, heat, pain, - should immediately consult a doctor, as

they can be symptoms of a serious disease-lower vein thrombosis

limbs'.

Indications:

Symptomatic treatment of lower limb vein disease (including varicose veins), characterized by chronic venous insufficiency, with symptoms such as pain and a feeling of heaviness in the legs, night cramps of calf muscles, skin itching and swelling of the legs.

Contraindications:

Hypersensitivity to any of the components of the drug.

With caution:

• concomitant administration with indirect anticoagulants
  
• age up to 18 years (efficacy and safety have not been studied).
  

Use during pregnancy and breast-feeding:

Not recommended during pregnancy and lactation, due to lack of clinical data.

Side effect:

Allergic reactions: feeling of heat, hives, skin rash, itching, rarely — anaphylactic shock, dyspepsia (including nausea).

In case of any adverse events, the drug should be discontinued and consult with your doctor.

Drug interaction:

Enhances the effect of indirect anticoagulants.

Dosage and administration:

Inside, before eating, in the morning and in the evening, without chewing, drinking a small amount of liquid.

1 table. 2 times a day the duration of treatment is determined by the severity of the symptoms of the disease.

Permissible long-term application.

Overdose:

No cases of overdose have been reported to date.

Treatment: in case of overdose, consult a doctor.

Special instruction:

The efficacy and safety of the drug in childhood has not been studied, so the appointment of the drug to children is not recommended.

It is necessary to strictly follow the additional instructions of the doctor-bandaging feet, wearing elastic stockings, cold foot baths!

In case of sudden appearance of severe symptoms (especially on one leg), — severe swelling, skin color change, a feeling of tension and heat, pain — you should immediately consult a doctor. These symptoms may be symptoms of a serious disease — thrombosis of the veins of the lower extremities.