Expiration date: 12/2025

The composition and form of issue: 

Tablets, coated enteric-soluble shell, 1 table contains natamycin 100 mg

Excipients: potato starch -79,2 mg PVP 5 mg magnesium stearate 2.5 mg lactose 66 mg gelatin and 3.3 mg acacia (gum Arabic) is 7.3 mg methyl-p-oxybenzoic — 0.07 mg calcium carbonate 30 mg kaolin — 14.2 mg talc — 21,7 mg of cellulose acetate phthalate — 18 mg triacetin — 2.7 mg wax, white bees — 0.13 mg titanium oxide 3 mg sucrose — 122 mg 

in vials of 20 PCs in a box 1 vial.

Vaginal suppositories, 1 supp. contains natamycin 100 mg

excipients: cetyl alcohol — 690 mg solid fat and 700 mg of sorbitol — 460 mg of Polysorbate 80 — 460 mg of sodium bicarbonate and 69 mg of adipic acid 64 mg 

in a contour bezgyachakova packing 3 pieces in a cardboard unit 1 or 2 packaging.

Cream for external use, 1 g contains natamycin 20 mg

excipients: decollet 100 mg wax-based esters atilovykh 50 mg cetostearyl alcohol — 135 mg sodium lauryl sulfate 15 mg methyl parahydroxybenzoate 2 mg parahydroxybenzoate 1 mg propylene glycol 150 mg water purified 

in tubes of 30 grams in a cardboard bundle 1 tuba.

Description pharmaceutical form:

Tablets, coated enteric-soluble shell: round, white.

Vaginal suppositories: torpedo shape, white with a yellowish tint to light yellow with brown tint.

Cream for external use from white to light yellow color.

Feature:

The polyene antifungal broad-spectrum antibiotic from the macrolides.

Pharmacokinetics:

Natamycin has only a local effect, not being absorbed from the gastrointestinal tract, through the skin and mucous membranes.

Description pharmacological action:

Natamycin irreversibly binds to sterols of fungal cell membranes, disrupting the integrity and functions, leading to death of microorganisms.

To natamitino most sensitive pathogenic yeast fungi, especially Candida albicans. Less sensitive to natamycin dermatophytes. Primary resistance to natamitino in clinical practice is not common.

Indications:

Pills

Fungal diseases of the skin and mucous membranes, caused by sensitive to the drug pathogens, including:

• and acute pseudomembranous acute atrophic candidiasis in patients with cachexia, immune insufficiency, and also after treatment with antibiotics, corticosteroids, cytostatics
  
• the otomycosis, external otitis, either initially caused by fungi or complicated by candidiasis
  
• candidiasis of skin and nails
  
• candidiasis of the intestine
  
• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by the fungi Candida
  
• ringworm
  
• as a complementary agent in the treatment of ringworm with griseofulvin.
  

Vaginal suppositories

vaginitis, vulvitis, vulvovaginitis, caused mainly by the fungi Candida.

Cream

fungal diseases of the skin and mucous membranes, caused by sensitive to the drug pathogens, including:

• vulvitis, vulvovaginitis, balanoposthitis, caused mainly by the fungi Candida
  
• candidiasis of skin and nails
  
• otitis externa, or primarily caused by fungi or complicated by candidiasis
  
• ringworm of the.
  

Contraindications:

Hypersensitivity to the drug.

Application of pregnancy and breast-feeding:

Perhaps the use of Pimafucin during pregnancy and breastfeeding. No data on adverse effects of the drug on the fetus.

Side effects:

From the blood: in some cases, the use of enteric-soluble tablets, especially in the first days of treatment, possible nausea and diarrhoea, usually pass on their own.

Local reactions: possible mild irritation, burning sensation (when using a cream, vaginal suppositories).

Drug interactions:

Drug interactions drug Pimafucin not described.

Method of application and dose:

Tablets, inside. At intestinal candidiasis adults — 1 tab. 4 times a day on average within 1 week. Children — 1 table. 2 times a day within 1 week.

Vaginal suppositories, vaginally. When vaginitis, vulvitis, vulvovaginal — 1 supp. within 3-6 days. Suppository inserted into the vagina in the lying position, as far as possible, 1 time a day at night. If persistent course of vaginitis caused by Candida albicans additionally prescribe Pimafucin in the form of tablets for oral administration (for 1 table. 4 times a day for 10-20 days) for the rehabilitation focus of Candida infection in the intestines. For the treatment of vulvovaginal defeat genitals partner use Pimafucin in the form of cream. Duration of treatment is determined individually. After the disappearance of symptoms is recommended to continue treatment for a few days.

Cream, topically. At vulvitis, vulvovaginitis, balanoposthitis cream applied to the affected areas 1 or several times a day. If persistent for vulvitis, vulvovaginitis caused by Candida albicans additionally prescribe Pimafucin in pill form orally or vaginal suppositories.

For ringworm (including candidiasis of skin and nails, diaper rash in children) cream applied to the affected surface of the skin and nails one or more (up to 4) times a day.

At mycosis external auditory meatus surface grease with a cream one or a few (up to 4) times a day. Before using the product purified by ear. After the drug is placed in the ear canal turundas from a natural material (cotton, wool).

Duration of treatment is determined individually. After the disappearance of symptoms is recommended to continue treatment for a few days.

Overdose:

To date, the cases of drug overdose Pimafuzin was not reported.

Special instructions:

Vaginal suppositories under the influence of body temperature quickly dissolved, forming a frothy mass, which contributes to uniform distribution of the active substance. In the case of chronic or recurrent infection topical treatment may be supplemented by the appointment of tablets and cream Pimafucin.

Cetyl alcohol, which is part of the vaginal suppositories, can cause a feeling of light burning in the genital area in case of hypersensitivity to the component. During menstruation suppositories interrupt therapy. During treatment with suppositories is not necessary to exclude sexual contacts. However, it is recommended to conduct a survey of sexual partners and, in case of detection of vulvovaginal lesions, a course of treatment Pimafucinom. Also, consider using a treatment period of barrier contraceptives.

You can assign pimafucin newborn.