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Expiration date: 12/2025

The composition and form of issue: 

Tablets, film-coated. 1 tablet contains:

levofloxacin (hemihydrate) 250 or 500 mg

excipients: microcrystalline cellulose starch povidone (K-30) crospovidone magnesium stearate avicel pH 101 (MCC) 

shell: hypromellose macrogol (polyethylene glycol 6000) dibutyl phthalate talc titanium dioxide dye iron oxide red (table. 250 mg) and dyes iron oxide red and iron oxide yellow (PL. 500 mg) 

in a contour acheikova package 5 PCs the paper cartons 1 or 5 packs.

Indications:

Infectious-inflammatory diseases caused by sensitive microorganisms:

  • of ENT-organs, including acute sinusitis
  • lower respiratory tract, including the exacerbation of chronic bronchitis, community-acquired pneumonia
  • urinary tract and kidney (uncomplicated and complicated infections), including acute pyelonephritis
  • genital organs, including the prostate
  • the skin and soft tissues (festering atheroma, abscess, furunkoulez)
  • intraabdominal infections in combination with drugs acting on the anaerobic microflora.

Contraindications:

  • hypersensitivity to levofloxacin and other fluoroquinolones
  • epilepsy
  • lesions of the tendons at the earlier treatment quinolones
  • pregnancy
  • lactation
  • childhood and adolescence till 18 years.

With caution:

  • old age (high likelihood of having a concomitant loss of kidney function)
  • the deficit glukozo-6-fosfatdegidrogenaza.

Method of application and dose:

Inside 1 or 2 times a day, with liquid squeezed enough liquid (from 0, 5 to 1 Cup), can be taken before meals or between meals. Doses are determined by the nature and severity of the infection, and the alleged sensitivity of the pathogen.

Patients with normal or moderately reduced renal function (creatinine Cl >50 ml/min) recommended dosage regimen of the drug:

Sinusitis: 500 mg 1 time a day for 10-14 days.

Exacerbation of chronic bronchitis: 250 or 500 mg 1 time a day for 7-10 days.

Community-acquired pneumonia: 500 mg 1-2 times a day 7-14 days.

Uncomplicated urinary tract infections: 250 mg 1 time per day — 3 days.

Prostatitis: 500 mg 1 time a day for 28 days.

Complicated urinary tract infections including pyelonephritis: 250 mg 1 time a day for 7-10 days.

Infections of skin and soft tissues: 250-500 mg 1-2 times a day 7-14 days.

Intra-abdominal infection: 500 mg 1 time per day for 7-14 days (in combination with antibacterial drugs acting on the anaerobic flora).

Table: The dosage in patients with impaired renal function

Creatinine Cl, ml/min

250 mg/24 h500 mg/24 h500 mg12 h
first dose:
250 mg		first dose:
500 mg		first dose:
500 mg
50–20then:
125 mg/24 h		then:
250 mg/24 h		then:
250 mg/12 h
19–10then:
125 mg/48 h		then:
125 mg/24 h		then:
125 mg/12 h
<10 (including hemodialysis and papd)then:
125 mg/48 h		then:
125 mg/24 h		then:
125 mg/24 h

After hemodialysis or continuous ambulatory peritoneal dialysis (APD) does not require the introduction of additional doses.

When the liver does not require special selection of doses, as levofloxacin is metabolized in the liver only in very small extent.

For elderly patients does not require changes in dosing regimen, except low Cl of creatinine.

As the use of other antibacterial agents, treatment with Glevo, it is recommended to continue at least 48-78 hours after normalization of body temperature or after reliable eradication of the pathogen.

If you skipped a dose, I needed to take the pill until almost time for the next appointment. To continue to take the drug under the scheme.

Glevo
(Levofloxacin)