Expiration date: 02/2025
Active substance: Benzyldimethyl-miristoilamino-propylammonium
Description pharmaceutical form:
Colorless transparent liquid, foam when shaken.
Pharmacokinetics:
When applied topically, it is not absorbed through the skin and mucous membranes.
Description of the pharmacological actions:
Miramistin has a broad spectrum of antimicrobial activity, including hospital strains resistant to antibiotics.
The drug has a marked bactericidal activity against Gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc.), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Etc.), Aerobic and anaerobic bacteria, determined as monocultures and microbial associations, including hospital strains with multidrug-resistant to antibiotics.
Has antifungal activity on Aspergillus genus Ascomycetes and the genus Penicillium, the yeast (Rhodotorula rubra, Torulopsis gabrata etc.), and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc.) dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.), as well as other pathogenic fungi in a monoculture and microbial associations including fungal microflora with resistance to chemotherapeutic drugs.
It has antiviral activity, particularly active in regard to a multi-structured viruses (herpes viruses, influenza, human immunodeficiency adenoviruses et al.).
Miramistin causes destruction of pathogens, sexually transmitted infections (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae, and others.).
Effectively prevents infection of wounds and burns. Stimulate defense reactions at the application site, by activating the absorption and digestive functions of phagocytes, potentiates the activity of the monocyte-macrophage system. Has expressed hyperosmolar activity, thereby relieves wound and perifocal inflammation, absorbs the purulent exudate, contributing to the formation of dry scab.
Stimulates epithelization and reparative processes in the wound, accelerates healing. Activates the processes of fibrinolysis in the inflammation. Do not damage the granulation and viable skin cells, it does not inhibit the edge epithelialization.
It does not have a locally-irritating to the mucous membranes and skin and has no allergenic properties.
Testimony:
Surgery, Trauma: Prevention and treatment of festering wounds festering. Treatment of inflammatory processes of the musculoskeletal system.
Obstetrics-gynecology: prevention and treatment of postpartum festering injuries, wounds of the perineum and vagina, postpartum infections, inflammatory diseases (vulvovaginitis, endometritis).
Combustiology: the treatment of superficial and deep burns, II and IIIA degree burn wounds to the preparation dermatoplastike.
Dermatology, venereology: treatment and prevention of pyoderma and ringworm, candidiasis of the skin and mucous membranes, foot mycoses.
Individual prevention of diseases, sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis, etc.).
Urology: complex treatment of acute and chronic urethritis and uretroprostatitis specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.
Dental treatment and prevention of infectious and inflammatory diseases of the mouth (stomatitis, gingivitis, periodontitis, periodontitis). Hygiene treatment for dentures.
Otorhinolaryngology: complex treatment of acute and chronic otitis, sinusitis, tonsillitis, laryngitis, pharyngitis.
Pediatrics (children aged 3 to 14 years): the treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis.
Contraindications:
Individual intolerance of components.
Side effect:
In some cases - a sense of light burning at the application site. Passes independently for 15-20 seconds and do not require discontinuation of therapy. Allergic reactions.
Drug Interactions:
While the use of antibiotics noted strengthening of their antibacterial and antifungal properties.
Dosage and administration:
Locally. The product is ready for use.
Notes on the use of packaging with a nozzle spray:
1. Remove the cap from the bottle.
2. Extract the attached nozzle spray from its protective packaging.
3. Attach the nozzle to the spray bottle.
4. Activate the nozzle spray by pressing.
Surgery, traumatology, combustiology. With the prophylactic and therapeutic purposes irrigate the surface of wounds and burns, loosely tamponiruyut wounds and fistulous passages, fix gauze pads soaked in the drug. Treatment procedure is repeated 2-3 times a day for 3-5 days. Highly effective method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug.
Obstetrics and gynecology. In order to prevent post-partum infection is used as a vaginal irrigations before delivery (5-7 days), after each delivery vaginal examination and postpartum 50 ml of the product in the form of tampons with an exposure for 2 hours to 5 days. When women delivery by Caesarean section, immediately before surgery treated vagina during surgery - the uterine cavity and the incision on it, and in the postoperative period are administered swabs soaked drug into the vagina with an exposure for 2 hours for 7 days. Treatment of inflammatory diseases of female genital mutilation is carried out in the course within 2 weeks of administration by intravaginal tampons with the drug, as well as by iontophoresis.
Venereology. For the prevention of sexually transmitted diseases drug is effective if it is used no later than two hours after intercourse. The contents of the vial with an applicator urological enter into the urethra for 2-3 min: men - 2-3 ml for women - 1-2 ml and in the vagina - 5.10 ml. Treat skin inner thighs, pubic area, genitals. After the procedure, it is recommended not to urinate for 2 hours.
Urology. In the complex treatment of urethritis and spend uretroprostatitis injection into the urethra of 2-3 ml of the drug 1-2 times a day, the course - 10 days.
Otorhinolaryngology. When purulent sinusitis - when puncture the maxillary sinus was washed with a sufficient amount of the drug.
Tonsillitis, pharyngitis and laryngitis treated gargling and / or irrigation using a spray nozzle, 3-4-fold by pressing 3-4 times a day. The amount of drug in the 1 rinse - 10-15 ml.
Pediatrics. In acute pharyngitis and / or exacerbation of chronic tonsillitis spend throat irrigation using a spray nozzle. Children aged 3-6 years - a single press on the head of the spray nozzle (3-5 ml per irrigation), 3-4 times a day for children aged 7-14 years - a two-time pressing (5-7 ml per irrigation) , 3-4 times a day for children over 14 years 3-4-fold by pressing (10-15 ml per irrigation), 3-4 times a day. Duration of therapy is 4 to 10 days, depending on the timing of the onset of remission.
Dentistry. If stomatitis, gingivitis, periodontitis is recommended to rinse the mouth for 10-15 ml of the drug 3-4 times a day.
