Expiration date: 03/2025
Structure and Composition:
Vaginal Suppositories .1 suppositorie contains 300 mg sertaconazole nitrate
Other ingredients: Witepsol suppotsir silicon dioxide colloidal anhydrous
in strip cellular pack 1 pcs. In the paper cartons 1 pack.
Description pharmaceutical form:
Suppositories oval waxy white.
Pharmacokinetics:
Systemic absorption after intravaginal application no. Unmodified sertaconazole not detected in either plasma or in urine.
Description of the pharmacological actions:
Sertaconazole - antifungal agent, and a benzothiophene derivative of imidazole. It has fungistatic and fungicidal activity at therapeutic doses. It is active against all species of Candida. Also possesses antibacterial activity against gram-positive bacteria (Streptococcus and staphylo-).
Inhibits the synthesis of ergosterol, it increases the permeability of the cell membrane, resulting in lysis of the cells of the fungus.
Indications:
Local treatment of infections of the vaginal mucosa caused by fungi of the genus Candida (vulvovaginal candidiasis).
Contraindications:
Hypersensitivity to imidazole derivatives, benzothiophene and other ingredients.
Application of pregnancy and breastfeeding:
Sufficient data on the use of sertaconazole during pregnancy and lactation is not. However, taking into account the route of administration (once), and the lack of systemic absorption after intravaginal administration, the use of sertaconazole during pregnancy and lactation is possible if the potential benefit to the mother outweighs the potential risk to the fetus or child.
Side effect:
Rare: burning sensation, itching in the vagina, which are their own and do not require discontinuation of therapy. Allergic reactions are possible.
Drug Interactions:
The simultaneous use of local contraceptives can lead to a weakening of spermicidal action of the latter.
Dosage and administration:
Intravaginally, once.
Before using the product it is necessary to wash the vulva with a neutral or alkaline soap.
One vaginal suppository is introduced deep into the vagina, lying on his back, before going to bed.
If clinical symptoms persist, it is possible re-introduction of the suppository in 7 days.
Overdose:
Not installed. In case of accidental ingestion of the drug is necessary to wash out the stomach and conduct symptomatic treatment.
Special instructions:
In the absence of characteristic clinical symptoms alone detection of Candida in the vaginal mucosa may be indication for the drug. If candidiasis is confirmed, it is recommended to identify and try to eliminate the factors that favor the emergence and development of fungi.
When simultaneous infection of the labia and the surrounding areas (candida vulvitis) should be further carried out by local drug treatment Zalain cream.
In applying the drug is recommended to abstain from sexual intercourse.
To prevent re-infection of the urogenital encouraged to consider the simultaneous treatment of sexual partners.
The risk of condom breakage or diaphragm increases when used simultaneously with the use of the drug.
Treatment can be performed during menstruation.
Zalain not affect the ability to engage in potentially hazardous activities that require special attention and speed of reactions (driving, etc.).
