Expiration date: 08/2025
Composition
The active substance - ketoconazole.
Pharmachologic effect:
Antifungal (fungicidal) antiandrogenic. Inhibits the synthesis of ergosterol, triglycerides, and phospholipids necessary for fungal cell wall synthesis, gives the permeability of the cell wall. If ingestion is well absorbed. Bioavailability is in direct proportion to the magnitude of the dose. The maximum concentration is reached after 2 hours. Associated with the protein, red blood cells. The dynamics of blood concentrations described biexponential curve. Able to penetrate into the cerebrospinal fluid. Undergo oxidative O-dezoksilirovaniyu, oxidative degradation and aromatic hydroxylation. Half-life is 2-4 hours. Provided in an unmodified form and in the form of inactive metabolites, 4 days shows 70% of the received amount (in the feces and urine). It is active against dermatophytes, yeast fungi of the genus Candida and molds, agents of systemic mycoses. Inhibit the formation of androgens, is effective in treating some forms of hormone dependent prostate cancer.
Testimony
skin fungal infections, hair and nails, caused by dermatophytes and / or yeasts (dermatophytosis, onychomycosis, candida paronychia, pityriasis versicolor, folliculitis, trihofitii) mycosis gastrointestinal tract mycoses eye, systemic mycosis (candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis, blastomycosis), cutaneous leishmaniasis, seborrheic dermatitis, dandruff, fungal sepsis, vaginal candidiasis, fungal infections in immunocompromised patients (prevention).
Contraindications:
Hypersensitivity, acute liver disease, pregnancy, laktatsiya.Ogranicheniya for use: Reduced function of the adrenal cortex and pituitary gland, severe renal and hepatic failure.
Side effect
Headache, dizziness, drowsiness, hair loss, nausea, vomiting, diarrhea, chronic hepatitis, transient increase in transaminases in the blood, photophobia, gynecomastia, decreased libido, and oligospermia, allergic reactions (urticaria, pruritus, arthralgia, paresthesia, hyperthermia).
Interaction
Incompatible with terfenadine, astemizole, alcohol. Weakens the effect of amphotericin B. Antacids, anticholinergics, H2-blockers significantly reduce the absorption of rifampicin and isoniazid - the concentration in the blood. It reduces a stimulating effect on the adrenal corticotropin. Inhibits microsomal oxidation both prescribed drugs and increases their concentration, enhances the toxicity difenina. Co-administration of oral contraceptives with a low content of hormones cause breakthrough bleeding.