Expiration date: 06/2025

Composition and form of issue:

Tablets, film-coated. 1 tablet contains:

amoxicillin trihydrate (based on amoxicillin) 250, 500 or 875 mg

and potassium clavulanate (in terms of clavulanic acid) 125 mg

excipients: lactulose (300 or 600 mg, respectively) crospovidon (kollidon CL) croscarmellose sodium talc magnesium stearate MCC 

shell excipients: hypromellose ethyl cellulose diethyl phthalate titanium dioxide talc 

in packs of contour cells 5 or 7 PCs in a pack of cardboard 1, 2 or 3 packages (for table. 250 + 125 mg and 500 + 125 mg) and 1 or 2 packages (for table. for 875+125 mg) or in bottles for 14 or 15 table. dosage 250 + 125 and 500 + 125 mg and 5, 7, 10 or 14 tables. dosage 875 + 125 mg in a pack of cardboard 1 bottle.

Method of application and doses:

Inside. Dosing regimen is set individually depending on the age and body weight of the patient, the severity of the course and the localization of the infectious process, as well as the sensitivity of the pathogen.

Minimum course of antibacterial therapy for 5 days. Treatment should not last longer than 14 days without review of the clinical situation.

Adults and children over 12 years of age or weighing more than 40 kg:

Light and moderate infections - 1 table. 250 + 125 mg 3 times a day or 1 table. 500 + 125 mg 2 times a day.

Severe infections or infections of the lower respiratory tract-1 table. 875 + 125 mg 2 times a day or 1 table. 500 mg + 125 mg 3 times a day.

Since the tablets contain the same amount of clavulanic acid (125 mg), it should be borne in mind that table 2. 250 + 125 mg is not equivalent to 1 table. 500 + 125 mg each.

The maximum daily dose of amoxicillin for adults and children over 12 years — 6 g, clavulanic acid-600 mg.

In chronic renal failure, the dose and frequency of administration are corrected depending on creatinine clearance:

• when Cl creatinine >30 ml/min dose adjustment is not required
  
• when Cl creatinine 10-30 ml / min — 1 table.250 + 125 mg 2 times a day (in mild and moderate infections) or 1 table. 500 + 125 mg 2 times a day (in severe infections or infections of the lower respiratory tract)
  
• with creatinine Cl <10 ml / min - 1 table. 250 + 125 mg 1 time a day (in mild and moderate infections) or 1 table. 500 + 125 mg 1 time per day (in severe infections or lower respiratory tract infections)
  
• patients on hemodialysis-1 table. 500 + 125 mg or 2 tables. 250 + 125 mg every 24 h in combination with 1 dose during hemodialysis and 1 dose after hemodialysis, as the concentration of amoxicillin and clavulanic acid decreases.