Expiration date: 12/2025
Composition: one bottle contains Cefazolin sodium 500 mg or 1000 mg.
Pharmacological action.
Cefazolin sodium salt is a broad-spectrum cephalosporin antibiotic. Has a bactericidal effect. Active against gram-positive bacteria: Staphylococcus spp. (strains producing and not producing penicillinase), Streptococcus spp. (including Streptococcus spp.), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria meningitidis, Neisseria gonorrhoae, Shigella spp., Salmonella spp., Escherichia coli, Klebsiella spp.. Active also in relation to Spirochaetaceae, Leptospira spp.. Inactive for Pseudomonas aeruginosa, indole-positive Proteus spp strains., Mycobacterium tuberculosis, anaerobic bacteria.
Reacts with specific penicillin binding proteins on the surface of the cytoplasmic membrane, inhibits the synthesis of peptidoglycan layer of the cell wall (inhibits transpeptidase, inhibits the formation of cross-links chains peptidoglycan), releases autolytic enzymes of the cell wall, causing damage and destruction of bacteria.
Indications of the drug.
Cefazolin is used in infectious and inflammatory diseases caused by microorganisms sensitive to it.
Indications for use of the drug are: infections of the upper and lower respiratory tract (acute bronchitis and exacerbation of chronic bronchitis, infected bronchiectasis, bacterial pneumonia, empyema and lung abscesses); infections of the ENT organs (including otitis media, mastoiditis); urinary tract infections (including acute and chronic pyelonephritis) ; infections of the biliary tract; infections of the skin and soft tissues (including carbuncle, phlegmon, wound and burn infections); bone and joint infections (including osteomyelitis, septic arthritis); gynecological and postpartum infections (including septic abortion, endometritis, postpartum infections); septicemia, endocarditis, peritonitis, syphilis, gonorrhoea; prevention of postoperative infectious complications.
Contraindications.
Hypersensitivity, including to other beta-lactam antibiotics, pregnancy, breast-feeding (at the time of treatment stop). Safety of the drug in children under 1 month of age and in premature infants is not established, so the use of Cefazolin sodium salt in this category of patients is not recommended.
